The Madison Isthmus is an isthmus in Madison, Wisconsin between Lake Mendota and Lake Monona. It is located between Madison's Northeast side to the east and the University of Wisconsin campus to the west. The south portion of the isthmus is home to the Wisconsin State Capitol, State Street, and Madison's main business and financial districts.[1] The street grid within the isthmus is laid out in a southwest-to-northeast pattern. Madison, Wisconsin is one of only two major U.S. cities built on an isthmus, the other being Seattle, Washington.